SEATTLE — Four people were killed Thursday in a crash between a charter bus and an amphibious tour vehicle in Seattle, officials said.

Harborview Medical Center spokeswoman Susan Gregg said the hospital expected to treat up to 10 of the most seriously injured victims, while as many as 15 others were being dispersed to other hospitals in the area.

The crash occurred on the Aurora Avenue bridge over Lake Union.

Sue Stangl of the Seattle Fire Department said emergency crews were quick to arrive at the scene and encountered several injuries. A dozen people suffered minor injuries.

“When (firefighters) arrived a lot of people were running at them, obviously saying people needed help,” Stangl.

The amphibious, military-style vehicles are operated by a tour company called “Ride the Ducks” and are known for exuberant drivers and tour guides who play loud music and quack through megaphones as they lead tourists around the city.

In July, the family of a woman struck and killed by an amphibious tourist boat in Philadelphia filed a wrongful-death lawsuit.

Attorneys for the family of Elizabeth Karnicki allege that the May 8 accident, which occurred during rush hour, was due in part to “huge blind spots” on the Ride The Ducks vehicle.

In 2010, a barge plowed into an amphibious vessel packed with tourists that had stalled in the Delaware River in Philadelphia.

The crash sent all 37 people on the duck boat into the river, but 16-year-old Dora Schwendtner and 20-year-old Szabolcs Prem never resurfaced. The Hungarians were visiting the United States through a church exchange program; their families have filed wrongful-death lawsuits.